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For GLP-1 Users
Your medication
burns fat.
Creatine
saves muscle.
GLP-1 drugs can strip up to 40% of weight loss from lean mass. Creatine monohydrate is the most studied supplement on earth for preserving muscle, strength, and metabolic health during caloric deficit. Xwerks Lift delivers 5g per scoop — pure, micronized, nothing else.
5g
Creatine
80
Servings
0
Calories
1
Ingredient
Micronized
Monohydrate
Zero Calories
139 Reviews
The GLP-1 Muscle Problem
You're losing weight.
But not just fat.
But not just fat.
GLP-1 medications suppress appetite and drive rapid weight loss. But that weight isn't all fat. Without intervention, a significant portion comes from the lean muscle mass your metabolism, strength, and long-term health depend on.
01
Up to 40% lean mass loss
Studies show GLP-1 users lose 20–40% of total weight from lean body mass — muscle, bone density, and metabolic tissue disappearing alongside the fat you want to lose.
PMC Orthopedic Review, 2025 · Frontiers in Nutrition, 2025
02
Strength declines with muscle
Less muscle means less strength, slower metabolism, and higher risk of regaining weight as fat once you stop or reduce your medication. The muscle you lose is hard to rebuild.
Obesity, 2023 · JAMA, 2024
03
Zero extra calories required
Unlike protein supplements, creatine has zero calories — making it the ideal muscle-protective tool when GLP-1s have already slashed your appetite and caloric intake.
ISSN Position Stand on Creatine
Creatine + GLP-1: The Research
The most studied supplement
meets the biggest muscle
preservation challenge.
meets the biggest muscle
preservation challenge.
PMC · Narrative Review 2025
Creatine + resistance training improves strength and lean mass in older adults
An accumulating body of evidence shows creatine (≥3g/day) combined with resistance training is a viable intervention for improving strength, whole-body lean mass, and regional muscle density.
Legacy Physicians · 2025
Creatine users maintained 95% of muscle mass during weight loss
Research shows individuals combining creatine with resistance training during weight loss maintained 95% of their muscle mass, compared to 85% in the control group — a critical difference for GLP-1 users.
Meta-Analysis · 20 RCTs · 2025
Significant increase in 1RM strength and decrease in body fat %
A meta-analysis of 1,093 participants found creatine plus exercise training significantly improved 1RM strength and reduced body fat percentage — exactly what GLP-1 users need during weight loss.
Compass Indy · Clinical Review 2025
Creatine maintains strength even during caloric restriction
Creatine preserves muscle strength and volume even without high protein intake or intense training. It creates a more anabolic environment by drawing water into muscle cells, reducing catabolism during GLP-1-induced caloric deficit.
Supplement Facts
Serving Size1 scoop (5g)
Creatine Monohydrate5g
Calories0
Carbohydrates0g
Sugar0g
Fat0g
Why Lift for GLP-1 Users
Zero calories.
Maximum protection.
Maximum protection.
- Zero calories, zero carbs, zero sugar — won't add a single calorie to your GLP-1-suppressed intake. Pure muscle protection without dietary cost.
- Preserves muscle during caloric deficit — creatine maintains an anabolic environment in muscle cells even when eating less, protecting against the lean mass loss GLP-1s accelerate.
- Maintains workout performance — keeps strength and power output high even as bodyweight drops, so your training stays effective throughout your GLP-1 journey.
- 5g clinically effective dose — the exact amount used in the studies. Pure micronized creatine monohydrate, the gold standard form.
- 80 servings per bag — nearly 3 months of daily muscle protection at $0.61 per serving.
- Unflavored, mixes into anything — add to your protein shake, water, or coffee. Disappears into whatever you're already drinking.
$49
/ 80 servings · $0.61 per serving
How to Use Lift on GLP-1s
Zero complexity.
Just consistency.
Just consistency.
Creatine doesn't depend on timing — it works through daily saturation. Take 5g every day with whatever you're already drinking. No loading required. Full muscle protection builds over 2–4 weeks.
5g
Daily
One Scoop, Any Time
Mix into water, protein shake, or coffee. Timing doesn't matter — consistency does. Unflavored means it won't change the taste of anything.
+
Stack It
Pair with Grow
Add Lift to your scoop of Xwerks Grow for the ultimate GLP-1 muscle protection stack: 25g protein + 5g creatine in one shake, 110 calories total.
2-4
Weeks
Full Saturation
Muscle creatine stores peak in 2–4 weeks of daily use. No loading phase needed. Just take 5g consistently and let the science do its work.
Common Questions
GLP-1 +
Creatine FAQ
Creatine FAQ
No. Creatine monohydrate is a naturally occurring compound — it doesn't interact with semaglutide, tirzepatide, or liraglutide. It works through a completely different mechanism (ATP energy production in muscle cells). Always consult your physician with specific medication questions.
Creatine typically causes a 2–4 lb increase in water weight within muscle cells during the first 1–2 weeks. This is intramuscular water — not fat gain — and it's actually a sign the supplement is working. It creates a more anabolic environment that protects muscle during caloric deficit. Your fat loss from GLP-1 medication continues unaffected.
Both are important — ideally you use both. But creatine provides a unique benefit protein can't: it directly fuels the ATP energy system that powers muscle contractions, maintaining workout performance even during severe caloric restriction. Plus, creatine has zero calories, making it ideal when GLP-1s have already slashed your appetite. Pair Lift with Xwerks Grow for the complete protection stack.
Zero. No calories, no carbs, no sugar, no fat. Lift contains exactly one ingredient: micronized creatine monohydrate. It won't add a single calorie to your daily intake — critical when GLP-1 medications have already reduced how much you eat.
The standard evidence-based dose is 5g per day — exactly what one scoop of Lift provides. No loading phase is required. Take 5g daily and your muscles will reach full creatine saturation in 2–4 weeks. Research in older adults and weight-loss populations consistently uses this dose.
Yes. Creatine monohydrate has over 1,000 peer-reviewed studies confirming its safety. The International Society of Sports Nutrition and American College of Sports Medicine both affirm it is safe for healthy individuals with long-term daily use. No cycling off is required.
Absolutely — this is the recommended GLP-1 muscle protection stack. Add one scoop of Lift (5g creatine, 0 cal) to one scoop of Grow (25g protein, 110 cal). You get the two most research-backed muscle preservation tools in one shake at just 110 calories total.
1,000+ Studies · Zero Calories · One Ingredient
Your medication handles
the fat. Lift protects
the muscle.
the fat. Lift protects
the muscle.
5g of pure micronized creatine monohydrate. 80 servings. Zero calories. The most researched, most proven muscle preservation tool available — and it costs $0.61 per day.
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Research Backed
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your physician before starting any supplement regimen, especially while taking prescription medications.